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Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Frontiers of Medicine   Pages 889-906 doi: 10.1007/s11684-023-0994-x

Abstract: Whole-genome sequencing was performed on 68 newly diagnosed Chinese PCNSL samples, whose genomic characteristics

Keywords： primary central nervous system lymphoma     whole-genome sequencing     TMSB4X     copy number variation    

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Plastic materials and water sources actively select and shape wastewater plastispheres over time

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1580-1

Abstract:

● Wastewater MPs exhibited resistomes and therefore health threats.

Keywords： Microplastics     Whole-genome metagenomic sequencing     Plastisphere     Plastic degradation     MHETase    

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Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 23-33 doi: 10.1007/s11684-017-0607-7

Abstract:

Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityIn recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing inWide applications of genome sequencing and data sharing in infectious disease surveillance networks will

Keywords： genome sequencing     genomic epidemiology     bacteria     surveillance     infectious diseases    

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Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Frontiers of Medicine 2012, Volume 6, Issue 1,   Pages 48-55 doi: 10.1007/s11684-012-0182-x

Abstract:

The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeThe increased efficiency and resolution of next-generation sequencing greatly facilitate the detectionComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomesequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy.The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides

Keywords： next-generation sequencing     cancer genome     whole genome sequencing     exome     transcriptome    

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TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 322-330 doi: 10.1007/s11684-015-0408-9

Abstract:

This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular

Keywords： TCGA     whole-transcriptome sequencing     HCC     liver cancer    

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Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 42-57 doi: 10.1007/s11684-014-0303-9

Abstract:

The advent of whole-exome sequencing (WES) has facilitated the discovery of rare structure and functionalCombining exome sequencing with linkage studies is one of the most efficient strategies in searchingWe illustrate the workflow of exome capture and sequencing to highlight the advantages of WES.

Keywords： genetics     whole-exome sequencing     Mendelian disease     disease gene    

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Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 280-289 doi: 10.1007/s11684-013-0265-3

Abstract: Accompanied by a powerful computational data analysis method, new genome-wide screening approaches wereThis review focused on advanced genome-wide screening approaches in fusion gene identification, suchas microarray-based approaches, next-generation sequencing, and NanoString nCounter gene expression system

Keywords： gene fusion     cancer     microarray     next-generation sequencing     NanoString nCounter system    

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Genome-resolved metagenomic analysis reveals different functional potentials of multiple Brocadia species

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 1, doi: 10.1007/s11783-023-1602-7

Abstract:

● Four Ca. Brocadia species were observed during the spontaneously enrichment.

Keywords： Anammox     Candidatus Brocadia     Functional potential     Cooccurring mechanisms     Swine wastewater treatment facilities    

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An introduction to the medicinal plant genome project

Shilin Chen, Li Xiang, Xu Guo, Qiushi Li

Frontiers of Medicine 2011, Volume 5, Issue 2,   Pages 178-184 doi: 10.1007/s11684-011-0131-0

Abstract: In recent years, genomics has developed rapidly with the application of next-generation sequencing technologyThis paper introduces the genome research of medicinal plants, including genome sequencing, assembly,

Keywords： genomics     medicinal plant     sequencing     application    

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Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 2, doi: 10.1007/s11783-021-1458-7

Abstract:

•Tryptophan protein, and aromatic protein I/II were the key identified proteins.

Keywords： Sludge pretreatments     Dissolved organic nitrogen     Proteins     Amino acids     Structural equation model     Metagenomicsequencing analysis.    

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A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Frontiers of Medicine 2023, Volume 17, Issue 2,   Pages 330-338 doi: 10.1007/s11684-022-0933-2

Abstract: In previous studies, the focus has been mainly on gene sequencing, and there has been a lack of researchpatients and to provide a basis for further study of the pathogenesis of the disease, we performed whole-exomeand Sanger sequencing on a large Chinese Clouston syndrome pedigree.

Keywords： Clouston syndrome     whole exome sequencing     GJB6 gene     novel variant     unique phenotype    

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Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 1,   Pages 4-4 doi: 10.1007/s11783-021-1438-y

Abstract:

Microplastics existing widely in different matrices have been regarded as a reservoir for emerging contaminants. Mariculture systems have been observed to host microplastics and antibiotic resistance genes (ARGs). However, more information on proliferation of ARGs and metal resistance genes (MRGs) in mariculture system at the presence of microplastics is needed.

Keywords： Antibiotic resistance genes     Metal resistance genes     Metagenomic analysis     Microplastics     Mariculture    

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Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Frontiers of Agricultural Science and Engineering 2017, Volume 4, Issue 3,   Pages 319-326 doi: 10.15302/J-FASE-2017161

Abstract: To identify selection signatures in the genome of Chinese Rongchang pigs, we generated a total of aboutBy combining these data with the publically available genome data of 10 Asian wild boars, we identified

Keywords： domestication     genome     pig     re-sequencing     selection    

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Insights from metagenomic, metatranscriptomic, and molecular ecological network analyses into the effects

Quan Zheng, Minglu Zhang, Tingting Zhang, Xinhui Li, Minghan Zhu, Xiaohui Wang

Frontiers of Environmental Science & Engineering 2020, Volume 14, Issue 4, doi: 10.1007/s11783-020-1239-8

Abstract: Furthermore, metagenomic and metatranscriptomic analysis revealed that most of the genera related to

Keywords： Chromium nanoparticles (Cr NPs)     Metagenomic analysis     Metatranscriptomic analysis     Molecular ecological    

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The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Frontiers of Agricultural Science and Engineering 2020, Volume 7, Issue 2,   Pages 171-180 doi: 10.15302/J-FASE-2019302

Abstract: However, new breeding methods combined with genome editing and somatic cell nuclear transfer or microinjectionRecent advances in precise genome editing technologies, especially clustered regularly interspaced shortnucleases and the state of the art and new insights into practical applications and social acceptance of genomeIt is concluded that the production of gene-edited ruminants is feasible and through improvements in genome

Keywords： bioreactors     breeding     engineered endonucleases     genome editing     ruminants    

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Title Author Date Type Operation

Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing

Journal Article

Plastic materials and water sources actively select and shape wastewater plastispheres over time

Journal Article

Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the

Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu

Journal Article

Exploring the cancer genome in the era of next-generation sequencing

Hui Dong, Shengyue Wang

Journal Article

TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways

Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng

Journal Article

Exome sequencing greatly expedites the progressive research of Mendelian diseases

Xuejun Zhang

Journal Article

Identification of cancer gene fusions based on advanced analysis of the human genome or transcriptome

Lu Wang

Journal Article

Genome-resolved metagenomic analysis reveals different functional potentials of multiple Brocadia species

Journal Article

An introduction to the medicinal plant genome project

Shilin Chen, Li Xiang, Xu Guo, Qiushi Li

Journal Article

Anaerobic digestion of sludge by different pretreatments: Changes of amino acids and microbial community

Journal Article

A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome

Journal Article

Metagenomic analysis on resistance genes in water and microplastics from a mariculture system

Journal Article

Genome-wide analysis reveals selection for Chinese Rongchang pigs

Lei CHEN, Shilin TIAN, Long JIN, Zongyi GUO, Dan ZHU, Lan JING, Tiandong CHE, Qianzi TANG, Siqing CHEN, Liang ZHANG, Tinghuan ZHANG, Zuohua LIU, Jinyong WANG, Mingzhou LI

Journal Article

Insights from metagenomic, metatranscriptomic, and molecular ecological network analyses into the effects

Quan Zheng, Minglu Zhang, Tingting Zhang, Xinhui Li, Minghan Zhu, Xiaohui Wang

Journal Article

The development and application of genome editing technology in ruminants: a review

Mengke YUAN, Yuanpeng GAO, Jing HAN, Teng WU, Jingcheng ZHANG, Yongke WEI, Yong ZHANG

Journal Article